A highly potent drug combining methamphetamine and fentanyl, carrying a significantly increased risk of overdose, has been detected in the Czech Republic, note health officials. The sample was obtained at a music festival, prompting urgent warnings from the National Centre for Monitoring Drugs and Addictions (NMS).
The discovery is raising alarms because users may unknowingly consume fentanyl, a synthetic opioid far stronger than heroin. In the Czech Republic, fentanyl has been linked to 15 deaths in the past year. Globally, similar drugs are responsible for hundreds of thousands of overdoses annually.
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Potential impact and health risks
Experts warn that combining fentanyl with other substances can be life-threatening even in small amounts. The risk is especially high for users unaware or unfamiliar of what they may be consuming.
“Fentanyl, even in minute doses, can cause severe respiratory depression and death,” NMS officials say. “The risk rises sharply when combined with depressants such as alcohol or benzodiazepines.”
The presence of this drug has practical implications for anyone navigating nightlife or festival environments. Overdose treatment requires immediate medical attention, and awareness of symptoms—extreme drowsiness, shallow or difficult breathing, or loss of consciousness—is critical. Emergency medical services should be called without delay if these signs appear.
Authorities also highlight naloxone, sold under brands such as Nyxoid, as an effective antidote to opioid overdoses. The drug is available at contact centers and through field program workers.
Police report that fentanyl is typically obtained through leaching prescription painkiller patches, often diverted from legitimate patients, or through gaps in pharmaceutical distribution. Fentanyl is estimated to be up to 50 times stronger than heroin and 100 times stronger than morphine, amplifying the risk posed by street drugs that include it.
A growing trend in synthetic opioids
The Czech alert reflects a broader international issue. In the United States and parts of Europe, synthetic opioids like fentanyl are driving sharp increases in overdose deaths, with authorities emphasizing preventive measures and public education campaigns.
The NMS advises drug users to remain vigilant, avoid taking substances alone, and keep naloxone on hand. Officials are monitoring the situation and coordinating with local police and festival organizers to prevent further distribution.
Authorities also encourage healthcare providers and emergency responders to maintain heightened awareness for cases of unexplained drowsiness or respiratory distress linked to suspected drug use. Public messaging campaigns are expected to continue, emphasizing safety and harm reduction.


